Welcome to the Ophthalmology Journal News page! This page will showcase the latest news from the world of Ophthalmology, as published by The British Journal of Ophthalmology (BMJ).
For the British Ophthalmology Journal Archives, please visit http://bjo.bmj.com/ .
These news items are mainly specific study results that are relevant to the layman.
We have also added another news page with more ‘general’ Opthalmogy news here: Opthamologist News.
Furthermore, we have added a page with general news articles about Eye Health here: Eye Problems Articles , which is a good read for both patients and Ophthalmologists alike.
Ophthalmology Journal News:
To evaluate the anatomical and visual outcomes of patients treated with ocriplasmin for the treatment of symptomatic vitreomacular adhesion (sVMA), including vitreomacular traction syndrome and macular holes.
Retrospective, interventional, single centre, case series.
Patients with sVMA.
Patients were treated with a single intravitreal injection of 0.125 mg ocriplasmin (Jetrea, Thrombogenics Inc, USA, Alcon/Novartis EU) with the reconstitution technique recommended by the manufacturer.
The primary study endpoint was the resolution of sVMA by spectral domain optical coherence tomography (SDOCT) at day 28. Secondary outcome measures included time to vitreous release, visual acuity (VA), changes in the optical coherence tomography (OCT) thickness and structure and macular hole closure rate.
17 patients were included in the study and resolution of vitreomacular adhesion (VMA) was verified by SDOCT in eight patients by day 28 (overall response rate of 47.1%, 8/17 eyes) with most patients experiencing VMA release by 7 days (41.2%, 7/17 eyes). Those who did not have VMA resolution showed no statistically significant change in VMA diameter as measured by horizontal and vertical 5-line raster scans at final follow-up (p=0.82 and p=0.75, respectively). The mean baseline Snellen VA was 20/49 and at final follow-up was 20/46 (p=0.59). The average central subfield thickness was 371 microns prior to treatment and 324 microns at final follow-up (range 191–767 microns, p=0.25). Patients meeting three of four positive predictors criteria (eg, no epiretinal membrane (ERM) at baseline, VMA diameter ≤1500 µm and phakic lens status) showed a response rate of 50.0% (seven of 14 patients); those meeting all four criteria (eg, younger than 65, no ERM at baseline, VMA diameter ≤1500 µm and phakic lens status) showed a response rate of 75.0% (three of four eyes). Transient outer segment ellipsoid zone loss was documented in seven patients and subretinal fluid presence following injection was noted in five patients. Four of the five patients with macular holes at baseline experienced resolution of their macular hole after injection.
This is the first study to quantify the extent of outer retinal changes seen in patients receiving ocriplasmin. Our initial experience with ocriplasmin shows a significant anatomical effect and is accompanied by transient changes in the outer retinal structures visualised by SDOCT.
To review the refractive outcome of cataract surgery in eyes with keratoconus.
We retrospectively reviewed the medical records of 64 consecutive patients (92 eyes) who underwent cataract surgery with implantation of a spherical intraocular lens (IOL). We recorded the method of refractive correction and the effect of the keratometry (K) on the biometry prediction error (BPE).
35 eyes had mild keratoconus (mean K<48 dioptres (D)), 40 had moderate keratoconus (mean K 48 D to 55 D) and 17 had severe keratoconus (mean K>55 D). Actual K values were used in all eyes with mild or moderate keratoconus with a target refraction of approximately –1.0 D in mild keratoconus and –1.5 D in moderate keratoconus that resulted in a mean BPE of 0.0 D and +0.3 D, respectively. The actual K values were used in eight of the 17 eyes with severe keratoconus with a mean target refraction of –5.4 D, which resulted in a mean BPE of +6.8 D. In the remaining nine eyes, a standard K value of 43.25 D was used with a mean target refraction of –1.8 D, which resulted in a mean BPE of +0.6 D.
Using the actual K values with a target of low myopia is a suitable option for spherical IOL selection for eyes with a mean K of ≤55 D. When there is severe keratoconus, the use of actual K values can result in a large hyperopic error and the use of standard K value in these eyes should be considered.
Khan AO, Abu-Safieh L, Eisenberger T, Bolz HJ, Alkuraya FS. The RPGRIP1-related retinal phenotype in children. Br J Ophthalmol 2013;97:760–4. In Table 1, HAMEED9, (patients 3,4,6,8,9), should say DRYJA10.
Dry eye is highly prevalent worldwide and its incidence is known to increase with age. Several clinical studies have demonstrated reduced tear secretion in older people, indicating that lacrimal gland function decreases gradually with age.
It has been reported that Excess caloric intake accelerates the aging process, and increases the risks for age-related diseases.
A cross-sectional survey was conducted in 2011 among all employees of a company in Osaka, Japan (N=672; age range 26–64 years). Tear volume was measured using the Schirmer 1 method. Participants aged ≥40 years were also examined for MetS.
The number of internet users in the UK has more than doubled over the past 7 years.
I read with interest the article by Chan et al
We welcome this opportunity to respond to the letter by Huisingh and McGewin
Nonetheless we do appreciate...
In vivo confocal microscopy (IVCM) allows detailed examination of the corneal nerves. Damage to V-1 can result in corneal anaesthesia and neurotrophic keratitis. It is not clear whether corneal anaesthesia is related to loss of nerves in the sub-basal plexus or not. We present evidence from patients with uniocular corneal anaesthesia and a normal sub-basal plexus demonstrating a lack of such correlation.
A 57-year-old woman with history of left trigeminal neuralgia for several years had unsuccessful left alcohol trigeminal root injection followed by a left microvascular decompression. Postoperatively she developed persistent dry eye symptoms. Visual acuity (VA) was 6/9. Her left cornea showed superficial punctuate epithelial erosions (SPEE). Corneal sensation (Cochet–Bonnet) was 60 (normal) in her right eye and 0 (absent) in her left eye. IVCM revealed normal stromal and sub-basal nerves with equal density on both sides (
A 46-year-old man presented with a...
A senior colleague has conducted a study and asks me to analyse their data. They give me an excel spreadsheet containing 80 observations of intraocular pressure (IOP)—40 of which were made after using drug A and 40 of which were made after using drug B (see
My colleague asks me to find out whether drug A or drug B is better in terms of reducing IOP. I think back to my medical school training and recall something called a t test, which I believe may be relevant. Using the internet I discover that there is indeed a t test and that the t test can be used to compare the means of two groups. I apply the test and feedback the results (including a two-tailed p value of 0.0024) to my colleague (see online supplementary appendix 1, figure S1 for results of...
Retinoblastoma (RB) is a childhood eye tumour. Dysregulation of DNA repair may not only influence pathogenesis but could also adversely impact on response to cytotoxic chemotherapy frequently used in RB therapy. We studied the expression of human apurinic/apyrimidinic endonuclease (APE1), a key multifunctional protein involved in DNA base excision repair in RB.
Expression of APE1 was evaluated by immunohistochemistry in a series of 55 RBs and in retina. In tumours, APE1 expression was analysed in cytoplasm and nucleus independently and correlated with histopathological features, including invasion, differentiation and International Intraocular Retinoblastoma Classification groups. Relative APE1 mRNA and protein expressions were evaluated by real-time PCR and western blot. The expression of APE1 in tumour groups was compared with retinal tissue.
APE1 cytoplasmic expression was observed in 98% and nuclear positivity was observed in 83% of tumours analysed. Tumour cells invading the optic nerve showed predominant cytoplasmic immunoreactivity. An inverse correlation between cytoplasmic and nuclear positivity was observed. Real-time PCR revealed an increase in APE1 transcripts compared with retina. Western blot revealed a decreased protein concentration compared with retinal tissue.
This is the first study of APE1 expression in RB. Our observation suggests that subcellular localisation of APE1 is altered in RB. APE1 could be a potential drug target in RB.
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