Opthamologists and opometrists

Opthamologist News

Welcome to the Opthamologist News page (Ophthalmologist News ).

This page is intended as a quick update on whats going on in the world of Opthamology, including ophthalmology studies, news and general articles. Have a browse and see if something catches your eye.

We have also added another  Opthalmology news page, that includes only the latest medical studies and results, so if you are an Opthamologist, then it is also worth a read: Ophthalmology Journal.

For our ‘General Eye Health’ news page, please see: Eye Health.

Enjoy reading.

Opthamologist News:

This article...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)

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Posted: September 1, 2014, 7:11 pm
Conclusions: This study validates the use of these plants by traditional health practitioners in managing the disease, and also suggests a new source for isolation of potential lead compounds against Onchocerca volvulus. (Source: BMC Complementary and Alternative Medicine)
Posted: August 31, 2014, 11:00 pm
Conclusions: The MT thinned before the retinal nerve fiber layer and this occurred with a particular sequence. Our results provide potential diagnostic information for LHON. (Source: BMC Ophthalmology - Latest articles)
Posted: August 31, 2014, 11:00 pm
ConclusionsWe have defined a syndrome associated with vitreal glial cell aggregates and neovascular proliferation from the optic nerve or retina, which leads to neovascular glaucoma. The inflammation and secondary glaucoma resulting from this syndrome appear poorly responsive to conventional medical therapies. The exact etiology of COGS remains undetermined, but a systemic etiology is unlikely. (Source: Veterinary Ophthalmology)
Posted: August 31, 2014, 11:00 pm
Debadatta Mukhopadhyay, Manoj Kumar Das, Sandipan Dhar, Maya MukhopadhyayIndian Journal of Dermatology 2014 59(5):502-504Biotinidase is a ubiquitous mammalian cell enzyme occurring in liver, serum and kidney. It cleaves biotin from biocytin, which is a cofactor for biotin dependent enzymes, namely the human carboxylases. Biotinidase deficiency is associated with a wide spectrum of neurological, dermatological, immunological and ophthalmological abnormalities. This is a case of a 3-year-old boy presenting with delayed developmental milestones, tachypnea, progressively increasing ataxia, alopecia and dermatitis, all which dramatically responded to high doses of biotin. (Source: Indian Journal of Dermatology)

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Posted: August 31, 2014, 11:00 pm
Brito J, Racinais S, Nassis GP (Source: Clinical Ophthalmology)
Posted: August 31, 2014, 8:54 pm
Conclusions: Both methods can be useful to follow the visual function of diabetic patients and should be used together to discriminate patients from controls, as well as to identify early signs of retinal damage. (Source: BMC Ophthalmology - Latest articles)
Posted: August 30, 2014, 11:00 pm
Authors: Pfeffer BA, Philp NJ Abstract This series of review articles highlights how in vitro models of RPE can be effectively used to understand essential functions of the RPE that are not only fundamental to epithelial biology, but also have direct relevance to the visual system. The issue contains reviews from experts in the field covering aspects of basic cell and epithelial biology, namely: the barrier properties of the RPE (Rizzolo, 2014), epithelial polarity (Lehmann et al., 2014), cytoskeleton (Bonilha, 2014), and lysosomes (Guha et al., 2014), as well as properties more unique to the RPE, e.g., vitamin A metabolism (Hu and Bok, 2014), bioenergetics (Adijanto and Philp, 2014), phagocytosis (Mazzoni et al., 2014), ion transport (Reichhart and Strauß, 2014), and melanin...

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Posted: August 30, 2014, 5:10 pm
Authors: Lehmann GL, Benedicto I, Philp NJ, Rodriguez-Boulan E Abstract The retinal pigment epithelium (RPE) comprises a monolayer of polarized pigmented epithelial cells that is strategically interposed between the neural retina and the fenestrated choroid capillaries. The RPE performs a variety of vectorial transport functions (water, ions, metabolites, nutrients and waste products) that regulate the composition of the subretinal space and support the functions of photoreceptors (PRs) and other cells in the neural retina. To this end, RPE cells display a polarized distribution of channels, transporters and receptors in their plasma membrane (PM) that is remarkably different from that found in conventional extra-ocular epithelia, e.g. intestine, kidney, and gall bladder. This char...
Posted: August 30, 2014, 5:10 pm
Authors: Reichhart N, Strauß O Abstract Ion channels and ion transporters play essential roles in the function of the retinal pigment epithelium (RPE). The use of cell cultures has been exploited as a key method for successfully identifying and studying ion channels and transporters of the RPE. Cultured RPE cells enable robust and long-lasting patch-clamp recordings, Ussing chamber investigations of the transepithelial transport within the isolated RPE, and analyses of the intracellular Ca(2+) or pH with fluorescent probes. Furthermore, cultured RPE can be transfected at high success rates, permitting the easy use of siRNA to study the involvement of ion channels on the molecular level. However, the expression patterns of the ion channels in the RPE appear to be a very sensitive m...
Posted: August 30, 2014, 5:10 pm
Authors: Boulton ME Abstract The retinal pigment epithelium contains three major types of pigment granules; melanosomes, lipofuscin and melanolipofuscin. Melanosomes in the retinal pigment epithelium (RPE) are formed during embryogenesis and mature during early postnatal life while lipofuscin and melanolipofuscin granules accumulate as a function of age. The difficulty in studying the formation and consequences of melanosomes and lipofuscin granules in RPE cell culture is compounded by the fact that these pigment granules do not normally occur in established RPE cell lines and pigment granules are rapidly lost in adult human primary culture. This review will consider options available for overcoming these limitations and permitting the study of melanosomes and lipofuscin in cell cu...
Posted: August 30, 2014, 5:10 pm
Authors: Guha S, Coffey EE, Lu W, Lim JC, Beckel JM, Laties AM, Boesze-Battaglia K, Mitchell CH Abstract Lysosomes contribute to a multitude of cellular processes, and the pH of the lysosomal lumen plays a central mechanistic role in many of these functions. In addition to controlling the rate of enzymatic degradation for material delivered through autophagic or phagocytotic pathways, lysosomal pH regulates events such as lysosomal fusion with autophagosomes and the release of lysosomal calcium into the cytoplasm. Disruption of either the steady state lysosomal pH or of the regulated manipulations to lysosomal pH may be pathological. For example, chloroquine elevates the lysosomal pH of retinal pigmented epithelial (RPE) cells and triggers a retinopathy characterized by the accumul...
Posted: August 30, 2014, 5:10 pm
ConclusionWe demonstrated the dependence of the critical angle kappa on the central part of the MIOL and on biometric parameters of the eye, especially on the effective lens position. According to these results, we conclude that shallow anterior chamber depth in connection with a higher angle kappa is an important risk factor for pronounced photic phenomena after implantation of a diffractive MIOL. (Source: Acta Ophthalmologica)

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Posted: August 30, 2014, 3:25 pm
Conclusion: Significant topographical changes could be detected in the macula of AU and IMU patients. Retinal thickness in the perifoveal rings was increased both in AU and IMU, but in the center only in IMU. Choroidal thickness seems to be unaffected by uveitis, even in the presence of macular edema, at least in the early stage of the inflammatory disease process. (Source: BMC Ophthalmology - Latest articles)
Posted: August 29, 2014, 11:00 pm
ConclusionsThis extraction technique allows for generation of large populations of canine uveal melanocytes in a relatively short period of time. This technique could be a useful tool for future studies investigating both normal cellular characteristics and alterations found in melanocytes from dogs with ocular melanocytic disorders. (Source: Veterinary Ophthalmology)
Posted: August 29, 2014, 11:00 pm
A pair of articles published this week in two of the most prestigious science journals describe the manipulation of memory with neurotechnologies capable of precisely targeting brain circuitry. One study used optogenetics to turn on and turn off memory associations, changing negative associations to positive ones, in mice. The other study used magnetic stimulation and functional magnetic resonance imaging to improve memory for words associated with faces, by boosting connectivity in a human brain memory circuit. As the field moves from descriptive studies to more mechanistic tuning of brain circuits, it will have to be mindful of unintended consequences. (Source: National Institute of Mental Health)

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Posted: August 29, 2014, 5:16 pm
Chem. Commun., 2014, Accepted ManuscriptDOI: 10.1039/C4CC05524A, CommunicationMeiran Xie, Wei Song, Huijing Han, Jianhua WuNovel double-stranded polyacetylene with perylene bisimide bridge has been efficiently synthesized by metathesis cyclopolymerization of bis(1,6-heptadiyne) derivative, and exhibited good solubility, highly thermal and oxidative stability, low LUMO energy level,...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Posted: August 29, 2014, 1:04 pm
Are patients with type 2 diabetes at a higher risk of developing cataracts? A new meta-analysis investigates the issue. BMC Ophthalmology (Source: Medscape Today Headlines)
Posted: August 29, 2014, 7:34 am
How frequently does Descemet membrane detachment occur after canaloplasty, and what are the best ways to manage this complication? Journal of Glaucoma (Source: Medscape Today Headlines)
Posted: August 29, 2014, 7:34 am
Authors: Y Huang, L Mei, B Gui, W Su, D Liang, L Wu & Q Pan (Source: Eye)
Posted: August 29, 2014, 6:00 am

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