Opthamologist News


Welcome to the Opthamologist News page (Ophthalmologist News ).

This page is intended as a quick update on whats going on in the world of Opthamology, including ophthalmology studies, news and general articles. Have a browse and see if something catches your eye.

We have also added another  Opthalmology news page, that includes only the latest medical studies and results, so if you are an Opthamologist, then it is also worth a read: Ophthalmology Journal.

For our ‘General Eye Health’ news page, please see: Eye Health.

Enjoy reading.

Opthamologist News:

CONCLUSIONS: The lens DOS in vitrectomised eyes is higher than in non-vitrectomised eyes. The importance of the vitreous in the maintenance of lens transparency is emphasised. PMID: 27012183 [PubMed - as supplied by publisher] (Source: Archivos de la Sociedad Espanola de Oftalmologia)

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Posted: March 27, 2016, 11:37 am
Authors: Ménard C, Rezende FA, Miloudi K, Wilson A, Tétreault N, Hardy P, SanGiovanni JP, De Guire V, Sapieha P Abstract Age-related macular degeneration (AMD) is a leading cause of blindness worldwide affecting individuals over the age of 50. The neovascular form (NV AMD) is characterized by choroidal neovascularization (CNV) and responsible for the majority of central vision impairment. Using non-biased microRNA arrays and individual TaqMan qPCRs, we profiled miRNAs in the vitreous humour and plasma of patients with NV AMD. We identified a disease-associated increase in miR-146a and a decrease in miR-106b and miR-152 in the vitreous humour which was reproducible in plasma. Moreover, miR-146a/miR-106b ratios discriminated patients with NV AMD with an area under the Receiver Oper...
Posted: March 27, 2016, 4:28 am
Authors: Wang H, Hartnett ME Abstract Neovascular age-related macular degeneration (AMD) is a complex disease in which an individual's genetic predisposition is affected by aging and environmental stresses, which trigger signaling pathways involving inflammation, oxidation, and/or angiogenesis in the RPE cells and choroidal endothelial cells (CECs), to lead to vision loss from choroidal neovascularization. Antiangiogenic therapies have greatly improved clinical outcomes in the last decade; however, vision improves in less than half of patients treated for neovascular AMD, and treatments remain inadequate for atrophic AMD. Many studies focus on genetic predisposition or the association of outcomes in trials of human neovascular AMD but are unable to evaluate the effects between diff...
Posted: March 27, 2016, 12:44 am
Conclusions: Our results demonstrate that VIP’s therapeutic effect on HREC, occurs in part, through the balance between the pro-inflammatory cytokine, TNF-α, and the pro-resolving mediator, RvD1. Although VPAC1 is considered the major VIP receptor, VPAC2 is predominantly expressed on HREC under both normal and high glucose conditions. (Source: Prostaglandins and Other Lipid Mediators)
Posted: March 26, 2016, 10:00 pm
Publication date: 2016 Source:Materials Today: Proceedings, Volume 3, Issue 5 Author(s): İbrahim Karteri, Serhan Uruş, Halil Özerli, Şükrü Karataş We have studied photovoltaic performance photodiodes based on reduced graphene oxide-iron oxide (RGO-Fe3O4) and multi-wall carbon nanotube-iron oxide (MWCNT-Fe3O4) nanocomposites. Characterization of the RGO-Fe3O4 and the CNT-Fe3O4 nanostructures is investigated in detail by X-ray diffraction (XRD), FT-IR spectroscopy and scanning electron microscope (SEM). RGO is synthesized using modified Hummers’ method oxidation of graphite powder. The photovoltaic properties of the RGO-Fe3O4/p-Si/Al and the MWCNT-Fe3O4/p-Si/Al photodiodes are analyzed. The maximum electrical power values of devices were found to be 12.9μW and 10.4μW under 1...
Posted: March 26, 2016, 10:00 pm
CONCLUSIONS: Intravenous infliximab may be considered as globe- and sight-saving therapy for tissue melt after B-KPro. PMID: 27015032 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Posted: March 26, 2016, 5:29 pm
CONCLUSIONS: Patients with VKC or AC were at increased risk of KC. They had more severe KC and should be closely followed up and intensively treated. PMID: 27014800 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Posted: March 26, 2016, 5:29 pm
["There is nothing more constant than change" - Heraclitus 535 BC]. Klin Monbl Augenheilkd. 2016 Mar;232(3):241 Authors: Lang GK PMID: 27011026 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)

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Posted: March 26, 2016, 4:56 pm
Authors: Nentwich MM, Maertz J, Rudolph G Abstract Optic disc drusen are an important differential diagnosis in the diagnostic evaluation of a prominent optic nerve head. Drusen of the optic disc occur in 0.34 to 2.4 % of human individuals and manifest themselves bilaterally in three of four cases. Drusen are found six times more often within histological sections than on funduscopic examination. It is known that optic disc drusen can occur in familial clusters without any other pathological ophthalmic findings. They can also be associated with retinitis pigmentosa, or with the Joubert or Alagille syndromes. Non-invasive diagnostic tools include fundus-autofluorescence (AF), optical coherence tomography (OCT) and ultrasound. Drusen of the optic nerve head are asymptomatic in most...
Posted: March 26, 2016, 4:56 pm
CONCLUSION: Our case series shows that there is a statistically significant decrease in IOP following RPE, and to a clinically relevant extent. The changes in PSA and IOP might be linked by changes in prostaglandin metabolism in the prostate and/or the seminal vesicles. This theory remains to be confirmed by further studies. The increase in IOP during the development of prostate cancer might also be linked to changes in prostaglandin metabolism and composition. It is conceivable that prostaglandin analogues could be developed to reduce IOP. PMID: 27011033 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)
Posted: March 26, 2016, 4:56 pm
This article therefore summarises the recent publications on this topic and discusses their relevance. Apart from common features such as VEGF-A affinity, the substances exhibit differences, including the stability of the VEGF-A/molecule complexes and the ability to neutralise angiogenic molecules other than only VEGF-A. At the cellular level, a variety of different methods have been used and the results are often inconsistent. It is therefore not yet possible to predict the clinical properties of VEGF-A neutralising substances on the basis of their known molecular properties or cellular effects. PMID: 27011031 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)
Posted: March 26, 2016, 4:56 pm
Authors: Burggraf MH Abstract A variety of different factors may participate in causing an accident or in influencing its course. These have different legal consequences in different areas of insurance. These differences are outlined for the assessment areas, together with the different states of evidence. In particular, it is discussed whether and under which conditions a trauma can indirectly (as a participating factor) either cause, trigger or exacerbate detachment of the retina. PMID: 27011032 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)

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Posted: March 26, 2016, 4:56 pm
This article gives an overview of major muscular dystrophies involving retinal function and their genetic origin, in order to guide differential diagnosis. PMID: 27011029 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)
Posted: March 26, 2016, 4:56 pm
Authors: Deutsche Ophthalmologische Gesellschaft, München PMID: 27011034 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)
Posted: March 26, 2016, 4:56 pm
Authors: Rudolph G PMID: 27011027 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)
Posted: March 26, 2016, 4:56 pm
Authors: Preising MN, Lorenz B Abstract From the ophthalmological view, albinism is a disorder of reduced pigmentation of the retinal and irdial pigment epithelium and the iris and choroid stroma. The reduced pigmentation is accompanied by morphological changes in the retina and the optic nerve. The functional relationship of these morphological changes is not yet well understood. This review summarises the genetic causes of reduced pigment synthesis and impaired pigment distribution, and discusses the variability of expression of albinism symptoms, in the light of other disorders affecting retinal development. PMID: 27011028 [PubMed - in process] (Source: Klinische Monatsblatter fur Augenheilkunde)
Posted: March 26, 2016, 4:56 pm
CONCLUSION: About three decades after conventional treatment of Coats' disease stage 2a, treated eyes maintained good VA, and stage 2b eyes did not progress to advanced stages. PMID: 27014383 [PubMed] (Source: Open Ophthalmology Journal)

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Posted: March 26, 2016, 4:54 pm
Authors: Masoumpour MB, Nowroozzadeh MH, Razeghinejad MR Abstract Filtering surgeries are frequently used for controlling intraocular pressure in glaucoma patients. The long-term success of operation is intimately influenced by the process of wound healing at the site of surgery. Indeed, if has not been anticipated and managed accordingly, filtering surgery in high-risk patients could end up in bleb failure. Several strategies have been developed so far to overcome excessive scarring after filtering surgery. The principal step involves meticulous tissue handling and modification of surgical technique, which can minimize the severity of wound healing response at the first place. However, this is usually insufficient, especially in those with high-risk criteria. Thus, several adjuvan...
Posted: March 26, 2016, 4:54 pm
Authors: Baig N, Kam KW, Tham CC Abstract Trabeculectomy has been the gold standard in reducing intraocular pressure (IOP) in glaucoma patients, no matter it is angle closure or open angle glaucoma. However in primary angle closure glaucoma, no matter the lens is cataractous or not, it is likely to be pathological, this thicker than usual lens, with or without a more anterior position, is often regarded as a strong contributing factor to angle closure. Lens extraction, no matter it is cataractous or clear, can theoretically eliminate this anatomical predisposing factor of angle closure, and thus IOP can be reduced. Based on recent results of a number of clinical trials, lens extraction alone or in combination with other IOP-lowering surgeries, may therefore play a more important ro...
Posted: March 26, 2016, 4:54 pm
This article reviews the use of lasers in different areas of glaucoma, including the shift from argon laser trabeculoplasty (ALT) to selective laser trabeculoplasty (SLT), laser trabeculoplasty as an initial treatment for glaucoma, new laser trabeculoplasty procedures under investigation, and other recent laser treatment modalities such as endoscopic cyclophotocoagulation and laser-assisted deep sclerectomy. PMID: 27014388 [PubMed] (Source: Open Ophthalmology Journal)

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Posted: March 26, 2016, 4:54 pm

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